Abstract
Recent advances in genetics, molecular biology, and molecular pharmacology have resulted in the development of molecularly targeted therapies. Targeting specific molecular pathways essential for the survival of cancer cells would personalize treatment with the potential to improve outcome and minimize toxicities. In this chapter, we review gene-based targeted therapies for cancer. Discussion focuses on replacement therapies for abnormal p53 function and FUS1 tumor suppressor gene-mediated molecular therapy using nanoparticles for systemic gene delivery.
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