Abstract
There is a renewed interest in developing high-intensity short wave capacitively-coupled radiofrequency (RF) electric-fields for nanoparticle-mediated tumor-targeted hyperthermia. However, the direct thermal effects of such high-intensity electric-fields (13.56 MHZ, 600 W) on normal and tumor tissues are not completely understood. In this study, we investigate the heating behavior and dielectric properties of normal mouse tissues and orthotopically-implanted human hepatocellular and pancreatic carcinoma xenografts. We note tumor-selective hyperthermia (relative to normal mouse tissues) in implanted xenografts that can be explained on the basis of differential dielectric properties. Furthermore, we demonstrate that repeated RF exposure of tumor-bearing mice can result in significant anti-tumor effects compared to control groups without detectable harm to normal mouse tissues.
Highlights
Hyperthermia has been used in the treatment of cancer for centuries
The majority of work in cancer hyperthermia has focused on this premise, but the mechanisms of cancer cell death after hyperthermia is an area of active investigation
The average calculated CEM43 values for liver tumor and normal liver was 1041.6 and 17.5, respectively. These findings demonstrate tumor-selective hyperthermia delivered by RF field exposure to mice bearing human liver cancer xenografts in situ
Summary
Hyperthermia has been used in the treatment of cancer for centuries. There are reports from as early as 3000 BC of the application of heat for cancer treatment by ancient Egyptians [1]. The first reports from a formal scientific investigation of cancer hyperthermia came from Busch and Coley in the late 19th century and described the disappearance of sarcomas after spontaneous fever secondary to erysipelas infection [2]. While treating cancer with hyperthermia is an age-old proposition, there are ongoing challenges to its application in the clinic. Advances in nanotechnology, molecular biology, and cancer research have set the path for the development of much more effective, tumor selective, non-invasive nano-hyperthermia systems
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