Abstract
Background We have recently observed that treatment of colon tumor cells with low concentration of paclitaxel increased the expression of several genes associated with antigen-presenting machinery. Since 5-fluoruracil (5-FU) is the main antineoplastic agent for colon cancer, in this study we aimed to evaluate: a) whether transfection of dendritic cells (DC) with drug-treated tumor cells RNA, enhances the effectiveness of DC-based vaccine; b) if the modulatory effects of vaccine can be observed in vivo, and c) if the combination of DC with low dose chemotherapy schedule improves the antitumor responsiveness.
Highlights
We have recently observed that treatment of colon tumor cells with low concentration of paclitaxel increased the expression of several genes associated with antigen-presenting machinery
Background We have recently observed that treatment of colon tumor cells
if the modulatory effects of vaccine can be observed in vivo
Summary
Marcela R de Camargo[1,2], Carolina M Gorgulho[1], Cecília P Rodrigues[1], Juliana CL Frederico[1,2], Fabiana A Zambuzi[1], Victoria E Galvão[1], Marcimara Penitenti[3], Ramon Kaneno1,2*. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. 30 September - 6 October 2012
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