Abstract
Chemotherapy has shown promising potential for overcoming various tumors in clinic, however, the chemotherapeutic strategy suffers from the lower therapeutic efficiency and boring side-effect. Self-delivery drug nanomedicine with high drug loading, precise controlled release, low excipients-trigged adverse reaction and high efficiency in treatment have been as one very promising strategy for promoting chemotherapy. Herein, we reasonably design a reductive stimuli-triggered molecular prodrug containing a camptothecin (CPT) and near-infrared hemicyanine dye (CyOH), which can be formed nanoassemblies (denoted as CyCPT) via nano-precipitated method for enhanced chemotherapy. Peculiarly, CyCPT not only improves the water-solubility of hydrophobic CPT but also has outstanding cellular internalization and tumor permeability, showing a remarkable kill-ability for various tumor cells. Meanwhile, the CyCPT shows excellent in-vivo biosafety. Overall, the self-delivery nanomedicine may present a potential appealing nanoplatform for tumor eradication.
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