Tumor necrosis factor receptor–associated periodic syndrome in a pediatric patient: A genetic diagnosis

Abstract

Periodic fevers are characterized by flares in inflammatory symptoms that punctuate general good health. There are clinical classification criteria in place to aid in the diagnosis of several hereditary recurrent fever syndromes and one nonhereditary syndrome. 1 Gattorno M. Hofer M. Federici S. et al. Eurofever Registry and the Paediatric Rheumatology International Trials Organisation (PRINTO). Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis. 2019; 78: 1025-1032 Crossref PubMed Scopus (182) Google Scholar Differential diagnosis in this case included syndromes such as the following: 1.Familial Mediterranean fever 2.Tumor necrosis factor receptor–associated periodic fever syndrome (TRAPS) 3.Mevalonate kinase deficiency 4.Cryopyrin-associated periodic syndromes 5.Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA)