Abstract
N-2,6-Dialkylphenylphthalimides were found to be strong enhancers of 12-O-tetradecanaylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-α production by human leukemia cell line HL-60. Among these compounds, 2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (PP-33) showed the most potent activity (optimum concentration of 10 μM), indicating that the bulkiness of the alkyl groups at the 2 and 6-positions of the phenyl ring moiety is crucial for the activity. Its fluorinated derivative, 2-(2,6-diisopropylphenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3-dione (FPP-33) showed the activity at very low concentrations (optimum concentration of 0.1 μM).
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