Abstract
Tumor necrosis factor: is it time to change the name?
Highlights
Among targets of biological agents, tumor necrosis factor remains in the exclusive group that has retained its historical name - or at least one of them
The other name for TNF, cachectin, seems long gone, arguably the metabolic actions of TNF are more relevant to the setting of inflammatory and autoimmune disease than a capacity to kill tumors
Rather than having the N in TNF stand for necrosis, I think that it should stand for necroptosis
Summary
Tumor necrosis factor: is it time to change the name? Among targets of biological agents, tumor necrosis factor remains in the exclusive group that has retained its historical name - or at least one of them. The other name for TNF, cachectin, seems long gone, arguably the metabolic actions of TNF are more relevant to the setting of inflammatory and autoimmune disease than a capacity to kill tumors.
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