Abstract
The clinical management of sepsis has benefited from breakthroughs in antimicrobial chemotherapy as well as other pharmacologic and technologic means of critical care support. Despite such advances, the course of patients suffering sepsis remains unpredictable and often protracted [1]. Disruptions of immunologic and metabolic homeostasis are well recognized sequelae of sepsis that contribute to the morbidity and mortality of chronic sepsis. In addition, variables related to the clinical status of patients prior to the onset of sepsis also appear to impact on the acute manifestations of sepsis.
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