Abstract
Letters and Corrections1 May 1990Tumor Necrosis Factor and HypermetabolismTimothy B. Seaton, MD, Nancy Coombe, Abraham Mittelman, MDTimothy B. Seaton, MDSearch for more papers by this author, Nancy CoombeSearch for more papers by this author, Abraham Mittelman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-9-715_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The role of tumor necrosis factor (cachectin) in the pathogenesis of cachexia from cancer and other chronic diseases remains to be fully explored. Tumor necrosis factor (TNF) inhibits lipoprotein lipase in vitro and causes depletion of fat stores and muscle wasting in animal models (1). We suggest that TNF may also be responsible for alterations in resting metabolic rate.We measured the resting metabolic rate and respiratory quotient in the fasting state by indirect calorimetry in two patients receiving a 24-hour infusion of human recombinant TNF-alpha (200 µg/m2body surface area daily) as part of a phase...
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