Abstract
Many studies have investigated the association between Tumor necrosis factor-α-308 G>A (rs1800629) and the risk of esophageal cancer. However, their results are inconsistent. Therefore, we performed a meta-analysis of available data to investigate any possible association between this polymorphism and esophageal cancer risk. We searched PubMed, EMBASE, Web of Science, and the CNKI database for articles published up to 2016. Crude and adjusted odds ratio with 95% confidence intervals were calculated using fixed or random effects models. We used a dominant model (GA+AA vs GG), a recessive model (AA vs GG+GA), an over-dominant model (GG+AA vs GA), and allele frequency (G vs A) to identify any association. Eleven studies with 5617 participants were included in the meta-analysis. Our results suggest that TNF-α-308 G>A (rs1800629) is not significantly associated with a risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma. For genetic association studies, negative results of meta-analysis have a high level of evidence, and these results are important in this era of high-throughput sequencing-based precision medicine.
Highlights
Esophageal cancer (EC) which is the most common tumor of the digestive system has two major subtype: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) [1, 2]
323 articles were excluded because they do not investigate the association between rs1800629 and risk of esophageal cancer and 11 articles were screened further
Of the 11 articles, 1 article was excluded because the genotype of the case-control group did not satisfy the Hardy-Weinberg Equilibrium (HWE), and 2 articles were excluded with the reason that their participants were same to the other
Summary
Esophageal cancer (EC) which is the most common tumor of the digestive system has two major subtype: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) [1, 2]. The survival rate of esophageal cancer is < 10% after five years [3], mainly because of its extremely aggressive nature and poor survival [4]. In 2016, an estimated 16,910 new esophageal cancer cases and 15,690 deaths occurred in United States [5]. Various factors can lead to EC: race, smoking, alcohol consumption, diet, nutrients, obesity and genetics [4]. We are still not familiar with the Genetic epidemiology. Some Genome-Wide Association Studies (GWAS) have shown that some single nucleotide polymorphisms (SNPs) are risk factors of EC [1, 6, 7]
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