Tumor Necrosis Factor-Alpha and Age-Related Pathologies

S V Topolyanskaya

doi:10.20514/2226-6704-2020-10-6-414-421

Abstract

Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in the pathogenesis of chronic inflammatory diseases as well as in aging. The increased levels of tumor necrosis factor-α leads to the onset and progression of various diseases, to severity of frailty, to disability and mortality of elderly persons. Tumor necrosis factor-α affects different risk factors for cardiovascular diseases, contributes to the onset and progression of atherosclerosis and related pathology. This cytokine can also aggravate various metabolic disorders, mainly — insulin resistance and diabetes mellitus. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (up to osteoporosis) and sarcopenia (up to cachexia). Currently available data confirm the important role of tumor necrosis factor-α in various age-associated disorders.

Highlights

Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review
Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in the pathogenesis of chronic inflammatory diseases as well as in aging
The increased levels of tumor necrosis factor-α leads to the onset and progression of various diseases, to severity of frailty, to disability and mortality of elderly persons

Summary

Introduction

Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. The authors declare no conflict of interests При старении повышается экспрессия фактора некроза опухоли-α (ФНО-α) и интерлейкина-6, а дисбаланс между провоспалительными и противовоспалительными цитокинами приводит к возникновению субклинического воспаления, ускоряет процессы старения и способствует возникновению различных возраст-ассоциированных заболеваний.

Results

Conclusion