Abstract
Background: Gastric cancer (GC) is the leading cause of cancer death in the world. Chronic inflammation is a predisposing factor of gastric carcinogenesis. TNF-α is a key pro-inflammatory cytokine secreted by macrophages and causes development of malignant diseases. It also plays an important role in chronic inflammation caused by Helicobacter Pylori. Therefore, TNF-α polymorphisms is studied in Helicobacter Pylori infected gastric cancer.
 Objective: To find out the high risk group of Helicobacter Pylori infected gastric cancer cases in Asian and Caucasian people.
 Methods: A total of 130 GC cases and 103 healthy controls from Jichi Medical School, Japan were studied. TNF-α genotype and allele frequency were studied by Restriction Fragment Length Polymorphism (RFLP).
 Results: Among the study population TNFa-308A was less frequent in Asian people than those of Caucasian. TNFa-238G allele was more frequent in H. pylori positive GC (p<0.036) cases.
 Conclusion: Findings of the study suggest that TNF-238G polymorphism of TNF-α gene may be closely associated with susceptibility to Helicobacter Pylori infected gastric cancer in Asian patients. This might be due to high cytokine production by TNF-238G allele.
Highlights
Gastric cancer (GC) is the leading cause of cancer death in the world
TNFa-238G allele was more frequent in H. pylori positive GC (p
Findings of the study suggest that TNF-238G polymorphism of TNF-α gene may be closely associated with susceptibility to Helicobacter Pylori infected gastric cancer in Asian patients
Summary
Gastric cancer (GC) is the leading cause of cancer death in the world. Chronic inflammation is known to be a predisposing factor of carcinogenesis of GC; high cytokine production may promote the development of cancer. Helicobacter pylori (H. pylori) infection plays a crucial role in gastric cancer pathogenesis.[1,2] Persistent inflammation caused by H. pylori infection induces hypochlorhydria and gastric atrophy, which are two early precursors of gastric cancer development. Genetic variations in genes encoding cytokines and their receptors, which determine the intensity of the inflammatory response to the bacteria, may contribute to individual differences in severity of outcome of H. pylori infection and progression of gastric lesions[3]. TNF-α is a key pro-inflammatory cytokine secreted by macrophages and causes development of malignant diseases. It plays an important role in chronic inflammation caused by Helicobacter Pylori. TNF-α polymorphisms is studied in Helicobacter Pylori infected gastric cancer
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