Abstract
Given that the NcoI polymorphism of the tumor necrosis factor-β (TNF-β) gene has been shown to be associated with tumor necrosis factor-α (TNF-α) secretory capacity, we know that this TNF-β gene polymorphism may influence insulin resistance. In Caucasians, 2 polymorphisms of the TNF-α promoter region (positions −308 and −238) have been reported to be associated with insulin resistance. Thus, we investigated how genetic variation in the TNF-β and TNF-α genes was associated with insulin resistance in 211 Japanese men. The frequency of the TNF-β gene polymorphism was 0.41, and insulin resistance, estimated by homeostasis model assessment (HOMA), was significantly lower in variant homozygotes versus wild-type allele. The frequencies of the −308 and −238 polymorphisms were 0.01 and 0.02, respectively, and these polymorphisms were not associated with insulin resistance. Our results suggest that the TNF-β gene polymorphism decreases insulin resistance, and that the −308 and −238 polymorphisms of the TNF-α promoter region are not a major contributing factor to insulin resistance in Japanese men. Copyright © 2000 by W.B. Saunders Company
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