Abstract
: Tumor microenvironment (TME) comprises many non-malignant cells that act as accomplices to support tumor. Both immune cells and stromal cells in TME play an essential role in regulating many aspects of a tumor, including tumor growth, metastasis and drug resistance. The complex interactions between malignant cells and non-malignant cells in the TME determine the fate of a tumor. A comprehensive understanding of the components of TME will help us to choose the right target for cancer therapy, especially immunotherapy. In this review, we discuss the phenotypes, functions and potential therapeutic value of various cellular components in the TME.
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