Abstract

MAGE-A proteins are testis-specific E3 ubiquitin ligase components whose expression is upregulated in many cancers. MAGE-A3 and -A6 act as oncogenes and recent work now shows that they degrade the central metabolic regulator AMPK, providing a novel mechanism for rewiring cancer metabolism.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call