Tumor-host relationships studied in vitro: Experiments with tissue slices

Abstract

The incorporation of thymidine-H 3 into DNA, and of adenine-8-C 14 into DNA and RNA, has been studied in slices of liver, spleen, kidney, and lung of normal rats, a group of rats bearing the Walker 256 carcinoma, and another group bearing the Jensen sarcoma. Similar experiments were carried out with thymidine-H 3 in rats bearing the Murphy-Sturm lymphosarcoma. An increased incorporation of the precursor was observed in the liver, spleen, and usually also in the lung of the tumor-bearing hosts, the spleen showing the greatest activity.