Tumor detection using computational fiberscope system

Abstract

A computational fiberscope system has been designed and developed to detect and quantify an optical source deep in a homogeneous medium by quickly determining tissue optical properties (absorption coefficient and transport scattering coefficient ). Our system determined the optical properties and with average difference of 2.0% and 14.8% between this study and reference. Location of source is 0.15 cm from reference position. Diffuse light was collected by an optical fiber based fiberscope with a detecting window at the end of it. The position and orientation of the detecting window of the fiberscope were controlled by a 3D tracking system and a rotary stage. During measurements, the detected signals were recorded using a high-speed data acquisition system. To test the ability of this algorithm to accurately reconstruct the features of an optical source deep in a homogeneous tissue medium, measurements were performed in a tissue simulating phantom (an aqueous suspension of 5.5 L 3% Liposyn-10%). The current method is effective for samples whose optical properties satisfy the requirement of the diffusion approximation. Our results indicate that the custom designed fiberscope system has a potential for tumor sensing in fluorescent applications on patients.