Abstract
Experiments were performed on 28 sexually mature Wistar rats divided into two equal groups. Rats were fixed in stereotactic apparatus and received 2.8×105 C6 glioma cells in 20 μl of F10 medium locally into frontal region of brain under ketamine-xylazine-acepromazine anesthesia. One group of rats (n=14) was implanted with 40×104 MSCs in 40 μl of low glucose DMEM medium into submucosa of nasal cavity. Further, only rats from this group received 40×104 mesenchymal stem cells (MSCs) intranasally in the form of a spray on a weekly basis. All 14 rats from the second group died within two months. Rats with implanted MSCs started to die in two and a half months. Two rats lived up to 8.5 months. One of these rats was decapitated, brain slices stained with hematoxylin-eosin and Nissl – and no tumor cells were found. A connective tissue scar was found at the site of injection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
