Abstract
Colorectal cancer (CRC) is the second leading cause of mortality among cancers after malignant tumors of respiratory system. One of the most significant prognostic features of CRC is tumor budding (TB), which isn’t widely implemented in clinical practice. The aim of this research: to find the prognostic criteria of recurrence and lethal outcome of CRR IIA and IIIB stages (рТ3N0-2M0), the ratio of tumors with certain differentiation in groups of research was taken equal. Material and methods. The group I was formed from primary CRC without recurrences. The main relapse-free survival time was 5 years (62.5 ± 16.5 months). The ІІ group – primary CRC with recurrences; ІІА – with recurrences during 5 years from the moment when the tumor was removed, without fatal outcome; ІІВ – with recurrences and lethal outcome from generalization of tumor process during 5 years from the moment when the tumor was removed. The microslides of CRC were made by using the standard methods. Results. TB was identified in 46.66 % (28/60) of CRC рТ3N0-2M0. The direct relationship between tumor grade and presence of TB was found (Р < 0.05), but TB didn’t define differentiation of the CRC. There was a statistically significant relationship between TB and metastatic spreading of CRC to regional lymph nodes (Р < 0.001). Metastasis was associated with 3 stage of TB, absence of metastasis was typical for CRC without TB. The tendency was found in a larger number of cases of the CRC with TB 3 stage among recurring CRC compared with CRC without recurrence, mainly due to the ІІВ group of the research. Inverse correlation between TB stage and time of recurrence appearance was found (Р < 0.05). TB in central tumor sites was followed by presence and higher stage of TB in peripheral tumor sites (Р < 0.05), that can be taken into account during biopsies of CRC. Conclusions. TB is a prognostic criterion of metastasis and time of recurrence appearance for CRC рТ3N0-2M0, which is mostly typical for tumors in patients with recurrences and lethal outcome at the taken equal ratio of tumors by differentiation.
Highlights
A – концепція та дизайн дослідження; B – збір даних; C – аналіз та інтерпретація даних; D – написання статті; E – редагування статті; F – остаточне затвердження статті
Metastasis was associated with 3 stage of tumor budding (TB), absence of metastasis was typical for Colorectal cancer (CRC) without TB
The tendency was found in a larger number of cases of the CRC with TB 3 stage among recurring CRC compared with CRC without recurrence, mainly due to the ІІВ group of the research
Summary
Ключові слова: пухлинне брунькування, колоректальний рак, рецидивування, прогноз. Мета роботи – оцінювання прогностичного значення ПБ для рецидивування та настання летального наслідку у хворих на КРР ІІА, ІІІВ стадій (рТ3N0-2M0) при рівному співвідношенні пухлин за диференціюванням у групах дослідження. ІІ група – первинні КРР із рецидивуванням: ІІА – з рецидивами впродовж 5 років після видалення пухлини, що не призвели до летального наслідку; ІІВ – із виникненням рецидиву та летальним наслідком від генералізації пухлинного процесу протягом 5 років після видалення первинної пухлини. Пухлинне брунькування виявили в 46,66 % (28/60) КРР рТ3N0-2M0. Визначили пряму залежність між диференціюванням КРР і наявністю ПБ (р < 0,05), але ПБ не визначало диференціювання КРР. Пухлинне брунькування – прогностичний критерій метастазування та терміну рецидивування КРР рТ3N0-2M0, характерний здебільшого для пухлин пацієнтів із рецидивуванням і летальним наслідком при рівному співвідношенні пухлин за диференціюванням
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
