Tumor-Associated Raynaud’s Phenomenon Exacerbated by Administration of Immune Checkpoint Inhibitors

Abstract

A 78-year-old man with no history of diabetes or hematologic or cardiovascular diseases was diagnosed with having stage IIIB squamous cell carcinoma of the lung. Two months before this diagnosis, the patient complained of discoloration of the fingertips owing to cold temperature. A wide range of laboratory tests was performed, including those for hepatitis B and C viruses, human immunodeficiency virus, disseminated intravascular coagulation syndrome, antinuclear antibodies, rheumatoid factor, antineutrophil cytoplasmic antibodies, anticardiolipin and antiphospholipid antibodies, serum complement levels, cold agglutinin, and cryoglobin.