Abstract
Tumor-associated macrophages (TAMs) are key cells in tumor-associated chronic inflammation, and can promote tumor growth, proliferation, angiogenesis, invasion, metastasis and chemotherapy resistance. Under different circumstances, macrophages can be polarized into classically activated macrophages (M1) and alternatively activated macrophages (M2). Cyclooxygenase 2, nuclear factor-κB, Toll like receptor (TLR) signaling pathway, anoxia, the protooncogene MYC, Notch signaling pathway and cytokines are all involved in the transition of TAMs from M1 to M2 phenotype. The phenotype and function of TAMs vary with tumor progression, so antitumor drug therapies targeting macrophages should depend on the stage of tumors. Key words: Macrophages; Neoplasms; Phenotype
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Dermatology and Venereology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
