Abstract
BackgroundTo study the association between Apelin expression and the clinical features and postoperative prognosis in patients with gastric cancer (Int J Cancer 136:2388-2401, 2015).MethodsTumor samples and matched adjacent normal tissues were collected from 270 patients with GC receiving surgical resection. The tumor and serum Apelin levels were determined by immunohistochemistry and ELISA methods, respectively. GC cell lines were cultured for migration and invasive assays.ResultsOur data showed that tumor Apelin expression status, instead of serum Apelin level, was closely associated with more advance clinical features including tumor differentiation, lymph node and distant metastases. Moreover, patients with high tumor Apelin level had a significantly shorter overall survival period compared to those with low Apelin expression and those with or negative Apelin staining. Our in vitro study revealed that the Apelin regulated the migration and invasion abilities of GC cell lines, accompanied by up-regulations of a variety of cytokines associated with tumor invasiveness.ConclusionOur data suggest that tumor Apelin can be used as a marker to evaluate clinical characteristics and predict prognosis in GC patients.
Highlights
To study the association between Apelin expression and the clinical features and postoperative prognosis in patients with gastric cancer (Int J Cancer 136:2388-2401, 2015)
There is no specific marker for early diagnosis and prognosis prediction, a number of proteins have been previously reported to be associated with the outcome of Gastric cancer (GC) patients [5,6,7,8]
There are a significant difference in Apelin expression status between patients with GC and with chronic gastritis (Table 2)
Summary
To study the association between Apelin expression and the clinical features and postoperative prognosis in patients with gastric cancer (Int J Cancer 136:2388-2401, 2015). There is no specific marker for early diagnosis and prognosis prediction, a number of proteins have been previously reported to be associated with the outcome of GC patients [5,6,7,8]. Apelin is a member of the endogenous ligand of the human G protein receptor, known as APJ [9]. Both Apelin and APJ are extensively expressed in blood vasculature and stimulate angiogenesis by prompting
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