Abstract

The Ministry of Health and Welfare of Japan supports the research on cancer chemoprevention within the framework of cancer research programs, because the increasing interest in cancer chemoprevention has been remarkable. However, the research on cancer chemoprevention is quite new in Japan. Therefore, we started to search for non-toxic inhibitory compounds against various cancers (anti-cancer agents as well as inhibitors of tumor promotion) from natural products; sarcophytols A and B, isolated from a soft coral, (–)–epigallocatechin gallate (EGCG), isolated from green tea infusion and morusin, isolated from the root bark of the mulberry tree. All these four compounds are inhibitors of tumor promotion induced by a tumor promoter, teleocidin, in two-stage carcinogenesis experiments on mouse skin. We would like to implement these non-toxic compounds in cancer chemoprevention in the near future.

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