Tumor Angiogenesis: Determined By VEGF Expression, MAGS Scoring, Doppler Study, As Prognostic Indicator In Carcinoma Breast

Abstract

Introduction: Tumor angiogenesis have been newly emerging prognostic indicator in many tumors including carcinoma breast. Various methods of assessment of angiogenesis are VEGF expression, MAGS scoring,Chalky counting, MVD, and Colour Doppler. We assessed VEGF, MAGS scoring and Doppler Ultrasound in patients of carcinoma breast and fibroadenoma. Material and Methods: 30 samples of carcinoma breast and 10 fibroadenomas had MAGS scoring and immunohistochemical staining for VEGF. All patients of carcinoma breast had Color Doppler examination by 7.5 MHz probe and Peak systolic velocity, Peak diastolic velocity, Resistivity index and Pulsatility index were studied. The values were related with various well known clinicopathologic parameters of carcinoma breast and also among themselves. Result : VEGF expression is significantly more diffuse and intense in lymph node positive and higher grade carcinoma breast (p<0.001). MAGS score was also higher in lymph node positive and higher grade carcinoma breast (p<0.001). Color Doppler was not related to any of the clinicopathologic parameters of breast cancer. Conclusion : Higher VEGF expression and higher MAGS score can be used as a poor prognostic indicator in carcinoma breast while colour Doppler failed to yield results as a prognostic marker.