Abstract
Radiostrontium and 99mTc pyrophosphate accumulated in bone reacting to tumor invasion but not in the experimental bone tumor itself. Both 67Ga and 99mTc bleomycin were concentrated in the tumor as well as in the reacting bone. This discrimination of tumor affinity from skeletal delineation was illustrated by radioisotopic imaging in rabbits. The finding appears to imply that scanning with 67Ga and 99mTc bleomycin would be of help in early diagnosis of bone metastases and in delimiting fields of surgery and teletherapy in the absence of detectable radiographic abnormalities.
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