Tumeurs germinales primitives du médiastin : expérience de l’Institut de cancérologie de Lorraine sur une période de 20 ans (1990-2012)

Abstract

The aim of this study is to report treatments results of patients with primary germ cell tumors (GCTs) of mediastinum. MethodsA retrospective review was done of 19 consecutive patients with mediastinal GCTs treated in “Institut de cancérologie de Lorraine” between 1990 and 2012. ResultsA total of 19 patients were enrolled in this study. Three patients had pure seminoma and 16 patients had non-seminomatous germ cell tumors. All patients were treated with cisplatinum based chemotherapy at a dose of 33.48mg/m2/week. At the end of chemotherapy, three patients (15.8%) had complete response and negative marker, seven of them (36. 8%) had partial response and negative marker, five of them (26.32%) had partial response and positive marker, three of them (15.8%) had progressive disease (refractory disease) and one patient died because of the disease during treatment. The 1-year and 5-year overall survival rates were respectively 78 and 36% and the progression-free survival rate was 43 %. When relapse occurred, this happened within a 13 month period. ConclusionOur study confirmed the good management of mediastinal GCTs in our institute with similar results compared to literature.