Tulathromycin – a semi-synthetic macrolidе antibiotic. I. Characteristics and antibacterial activity

Abstract

This article reviews the available literature on the characteristics and antimicrobial activity of the semi-synthetic macrolide antibiotic tulathromycin from the triamilides subclass. The product has a high activity against Gram-negative respiratory pathogens and desirable pharmacological characteristics for high and persistent tissue levels in domestic animals. Representatives of the macrolide and lincosamide group are investigated and the similarities and differences from tulathromycin are outlined. It is emphasised that at the background of increasing bacterial resistance to a number of antimicrobial agents, only few tulathromycin-resistant strains of P. multocida and M. haemolytica have been reported so far. Tulathromycin is considered highly effective against common bacterial agents of respiratory diseases in large ruminants, pigs and sheeps, and may be an alternative for control of resistant bacterial pathogens