Abstract
Recently, tubular structures 18 - 26 nm in diameter have been found within endoplasmic reticulum (ER) of endothelial and other cells in a number of conditions including normal monkey tissue, renal biopsies from human lupus erythematosus and other diseases, a variety of sarcomas, lymphomas, and leukemias, and several viral infections both in vivo and in vitro. The structures have in common a convoluted tubular form, near uniform diameter, and general appearance suggesting a resemblance to the myxoviruses.We have observed similar particles within the ER of endothelial cells within the cerebral lesions caused by herpes simplex virus (HSV) both in experimentally infected rabbits and in a human case of herpes simplex encephalitis.Rabbits inoculated on the cornea with HSV developed focal encephalitic lesions in the brainstem within 4 days; cells within the lesions contained HSV.
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