Abstract
The incidence of tubular proteinuria measured as urinary excretion of beta 2-microglobulin was evaluated in 68 consecutive renal calcium stone formers, 14 of whom had impaired urinary acidification capacity. During normal conditions 13% of these stone formers had tubular proteinuria. There was no statistical difference in the incidence of tubular proteinuria between subgroups with proximal or distal acidification defects. During transient metabolic acidosis induced by an ammonium chloride load a pronounced increase in beta 2-microglobulin excretion was noticed in all patient groups but especially in those with urinary acidification defects. In stone formers with normal acidification capacity the degree of acidosis-induced beta 2-microglobulinuria was moderate but a small group of patients exhibited a large urine excretion of beta 2-microglobulin. This finding may reflect a latent tubular defect of importance for stone genesis.
Highlights
Studies of urol ithiasisdiseaseusually have focused on physico-chemical urine investigations and mineral metabolic problems [8]
The incidence of tubular proteinuria measured as urinary excretion of p2microglobulin was evaluated i n 68 consecutive renal calcium stone formers, 14 of whom had impaired urinary acidification capacity
During normal conditions 13% of these stone formers had tubular proteinuria
Summary
Studies of urol ithiasisdiseaseusually have focused on physico-chemical urine investigations and mineral metabolic problems [8]. The importance of renal function has not drawn much attention. Some studies of renal function i n renal calcium stone formers, tubular function,were reported (1, 3 , 11, 12). Tubular proteinuria indicates tubular dysfuction [9]. Such signs of tubular defects seem t o be rather comnon among renal calcium stone formers [1]. The present study was carried out i n order toinvestigatetheincidence of tubular proteinuria i n subgroups of stone formers w i t h various urinary acidification ability. The aim was alsotostudyifatransient metabolic acidosis could provoke a tubular proteinuria i n these stone formers
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