Abstract
Chitosan is a natural, biodegradable, non-toxic and biocompatible polymer, with characteristics such as a healing, hemostatic, antimicrobial agent, among others. Therefore, the aim of this study is to develop a tubular chitosan device for use as a prosthetic coating application in vascular surgery. The chitosan wires were obtained by the spinning method in a 2M sodium hydroxide coagulant solution (NaOH) and used in the form of wires and screens as a reinforcement structure to obtain the tubes. In order to characterize the tubes, optical microscopy, contact angle, degree of swelling, in vitro biodegradation, cytotoxicity and tensile strength were used. The results indicated that the tubes have uniformity over the entire length and as for the resistance to the trace, the tube reinforced with mesh presented greater deformation, while the tube reinforced with wire presented a higher value of rupture stress. The degree of swelling was higher in chitosan tubes with mesh. As for the biodegradation test, it was observed that the lysozyme samples showed greater loss of mass and the cytotoxicity test confirmed the cell viability of the material, concluding that the tubes reinforced with chitosan wires are promising for use in vascular surgeries.
Highlights
Biomaterials can be understood as substances, natural or synthetic, designed and shaped in such a way that they can be used for a period of time in the organism, so that alone or as part of a system, it directs and controls interactions with living components, in diagnostic or therapeutic procedures, in human or veterinary medicine (Keane & Badylak, 2014; Park & Lakes, 2007; Williams, 2008).Polymeric biomaterials, mainly based on chitosan, constitute a class of materials with several applications related to tissue engineering
Chitosan tubes reinforced with woven and spun yarns were manufactured for medical intervention purpose
MO results revealed that chitosan tubes are a dense, smooth and pore-free surface compared to chitosan tubes with yarns as a result of the wovens structural presence
Summary
Mainly based on chitosan, constitute a class of materials with several applications related to tissue engineering They have been used in several fields in the medical sciences, from controlled drug release to tissue engineering (Gomes et al, 2008). Chitosan is a linear biopolymer generally obtained by alkaline desacetylation of chitin, which is a polysaccharide consisting of 2-acetamide-2-deoxy-D-glucopyranose units linked via β (1→4) linkage. It has great economic and environmental importance as it is obtained from chitin, which is the second natural polymer present in nature (Chen, Kuo, & Lee, 2012). It is studied as an important constituent of biomaterials useful for the treatment of wounds, since it can accelerate the healing of injuries, in the prevention of infections, in the development of membranes for hemodialysis, and other functions, such as in development of films with action antimicrobial for preserving meats, fruits and cereals
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
