Tuberculosis in patients with underlying thalassemia: a consideration of common antioxidative pathway − an expressional analysis

Abstract

Background Tuberculosis is a common medical problem in the present day. The occurrence of this infection among the patients with congenital underlying disease is very interesting. Here, the authors study on the common pathways regarding the antioxidative process of tuberculosis and thalassemia, a congenic hemoglobin disorder. Materials and methods This work is a bioinformatics expressional analysis. The authors performed common pathway analysis and interrelationship identification for expressional pathways regarding antioxidative process of tuberculosis and thalassemia. Results The common pathway via glutathione can be shown and imply the increased risk for tuberculosis among the patients with underlying thalassemia. Conclusion Based on identified common antioxidative pathway, patients with thalassemia might be prone to acquire tuberculosis infection.