Abstract
Tuberculosis in children is still a challenge for world health problems, especially in establishing a diagnosis. Under diagnosis or over diagnosis can occur in some cases, so getting accurate data is still a challenging task. Clinical symptoms that are not typical in children add to the difficulty of diagnosis enforcement, especially in areas with a high incidence of TB infection. There has been much development of diagnostic TB methods in children, including genetic approach. Some studies report that miRNAs play an essential role in tuberculosis pathogenesis. MicroRNA as one of the diagnostic genetic methods can distinguish the incidence of latent and active infection in tuberculosis cases in children.
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