Tu2045 CYP2E1, Aldh2, Adh2 and ADH3 Gene Polymorphisms in Alcoholic Liver Disease Patients

Abstract

included. In a group comparison, TGFβ1 expression was significantly elevated (p,0.045) in the adipose tissue of patients with depression and/or anxiety and positively correlated with the presence of depression and/or anxiety (r=0.34, p,0.04). Of the clinical parameters, TGFβ1 levels were negatively correlated with grade of steatosis (r=-0.40, p ,0.0026), as well as other individually scored components of NASH histopathology, including scores for Kupffer cells (r=-0.36, p,0.002), lymphocytes (r=-0.30, p,0.01) and polymorphonuclear leukocyte cell infiltration (r=-0.29, p,0.012). Nevertheless, TGFβ1 expression levels were not different when group comparison was performed according to BMI, presence of NASH or hepatic fibrosis. Conclusion: Increased inflammatory cytokine signaling is implicated in depression and anxiety disorders. The elevation of TGF β1, one of the master regulators of Th1/Th2 signaling pathways, in adipose of morbidly obese subjects may contribute to the development of depression and anxiety in this cohort. On the other hand, the levels of TGFβ1 decrease with an increase in histologic inflammatory scores of patients with NASH. Our observations point towards the complexity of the relationship between NAFLD/NASH and depression/anxiety disorders in obese patients which warrant future investigations.