Abstract
19.85, 13.14, 8.94 μmol/L in MKN45 at 24, 48, and 72 hours, respectively. MK-2206 enhanced apoptosis in SGC-7901 and increased the expression level of cleaved PARP. The combination therapy of MK-2206 and doxorubicin or 5-fluorouracil, showed a synergistic pattern of combination indexes in SGC-7901 and MKN45 cells, indicating an enhanced inhibition by MK-2206 co-treatment. Furthermore, a small dose (1 μmol/L) of MK-2206 was sufficient for complete inhibition of chemotherapeutic-alteration of pAkt expression and significant enhancement of pro-apoptosis effect through the activation of caspase pathway. Conclusion MK-2206 could effectively inhibit gastric cancer cell growth by attenuation of Akt phosphorylation. Additionally, MK-2206 could synergistically enhance the antitumor effect of doxorubicin or 5-fluorouracil via caspase-dependent apoptosis.
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