Abstract

G A A b st ra ct s time, neural innervation appeared to be disrupted in early PanIN lesions. Conclusions: UEAI is a specific cell surface marker to bind the PanIN. Alterations in vascularization and innervation are prominent in PanIN bearing-mice and may contribute to the earliest events in PanIN formation. The combination of fluorescent labeling and 3-D microscopy provides a new method to visualize PanIN to aid early detection and diagnosis of pancreatic lesions and cancer. Further research on the serial evolution of these changes may provide insight into the pathogenesis of pancreatic cancer.

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