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Abstract
G A A b st ra ct s parameters were dichotomized, IPF was associated with increased abnormal distal nonacid reflux (57.9% vs. 26.3%, p=0.03). Trends in increased abnormal proximal bolus reflux (21.1% vs. 5.3%) and abnormal distal bolus reflux (31.6% vs. 15.8%) in IPF compared to NF were also observed but did not reach statistical significance. Conclusion: Increased reflux parameters on pre-lung transplant MII-pH were observed in IPF patients compared to NF patients with similar pulmonary function. IPF patients also had significantly more abnormal nonacid reflux compared to NF subjects. Our results suggest that microaspiration likely plays a role in chronic inflammation and fibrosis in IPF patients. The majority of IPF patients had abnormal nonacid reflux, which may explain the inconsistent response to acid suppression. Anti-reflux therapy such as fundoplication may provide more clinical benefit compared to anti-secretory medications in these patients.
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