Tu1845 Intestinal Epithelial CD98 Plays a Role in the Host Defense Response to Intestinal Inflammation

Abstract

conditions, confirming prior observations on the redundant role of ABL and ARG kinases under these circumstances. In further studies, we have identified in library screening experiments several additional promising kinase inhibitors that significantly blocked bacterial attachment to cultured epithelial cells. Several of these inhibitors target kinase pathways not previously known to be involved in EPEC attachment. Together, these data provide new insights into the possible utility of kinase inhibitors in treating and preventing infections with EPEC and perhaps other A/E pathogens. Use of Animals: All animal studies were reviewed and approved by the University of California, San Diego Institutional Animal Care and Use Committee.