Abstract
elimination groups. Co-administration of PPI was more prevalent in delayed elimination group compared with normal elimination group (90% vs. 62%). No difference was found in NSAIDs or vancomycin co-administration between the groups. Multivariate logistic regression model adjusted for age and gender revealed that co-administration of PPI was an independent factor associated with delayed MTX elimination (OR 12.3, p=0.04). Conclusion: Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in patients with high-dose methotrexate therapy.
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