Abstract
G A A b st ra ct s neurons. In contrast to control rats, UK14304 decreased the amplitude of IPSC in 12 of 17 rats that underwent homotypic stress (2hrs restrain, 20min forced swim, 40min cold @4°C and 2hrs water avoidance) for 5 days in a concentration-dependent manner (91±1%, 78±1% and 53±9% of baseline amplitude in response to perfusion with 0.1, 1 and 3μM, respectively; P<0.05 vs control). Pretreatment with CRF had no additional inhibitory action on the UK14304-induced inhibition of GABAergic currents. Miniature strain gauges were applied to the anterior corpus of anaesthetized rats to record gastric motility. In control rats, DMV microinjections of the indirect sympathomimetic tyramine (4.5nmoles/60nl) reduced gastric motility to 50±10% of baseline (N=10); conversely, microinjections of tyramine in the brainstem of homotypic stress rats decreased gastric motility to 7±5% of baseline (N=2). These data suggest that homotypic stress induces an upregulation of catecholaminergic, including α2-mediated, responses in vagal neurocircuits resulting in an exaggerated vagallymediated gastroinhibition. Supported by DK55530 and DK78364
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