Tu1722 Does Antibody Producibility Affect the Serum Anti-Helicobacter pylori Immunoglobulin G Antibody Titer?

Abstract

Tu1722 Does Antibody Producibility Affect the Serum Anti-Helicobacter pylori Immunoglobulin G Antibody Titer? Hyun Ah Chung*, Sun-Young Lee, Jeong Hwan Kim, Hyung Seok Park, Chan Sup Shim, in-Kyung Sung Department of Internal Medicine, Kunkuk University School of Medicine, Seoul, Korea (the Republic of) Background/Aims: Serum antibody titer differs according to the antibody producibility of the host. Hepatitis B vaccination is performed to all Koreans in the infancy or childhood supported by the national insurance, but some do not produce hepatitis B virus surface antibody (HBsAb) after the vaccination. The aim of this study was to elucidate whether the serum anti-H. pylori IgG antibody titer is related to serum HBsAb titer in Korean adults. Methods: Consecutive Korean adults with positive Giemsa staining who underwent serum pepsinogen (PG) assay, anti-H. pylori IgG antibody test, hepatitis B virus surface antigen (HBsAg)/antibody test, and endoscopic biopsy for H. pylori evaluation on the same day were included. Subjects were excluded if they were under 20 years old, showed a positive HBsAg finding, had a recent history of medication, or were in immunocompromised state. Results: Of 158 Korean adults who fulfilled the study inclusion criteria, 107 subjects (67.7%) showed marked H. pylori infiltration based on the Updated Sydney System, whereas 33 (20.9%) and 18 (11.4%) showed moderate and mild infiltration. The serum anti-H. pylori IgG antibody titer was significantly correlated with the amount of H. pylori infiltration on gastric biopsy (p!0.001), PG II concentration (pZ0.012), and PG ratio (p!0.001), but not to the serum HBsAb titer (pZ0.649) and PG I concentration (pZ0.115). The serum HBsAb titer in the subjects with marked H. pylori infiltration on the gastric biopsy was not different from those of the subjects with moderate and mild H. pylori infiltration (pZ0.505). Conclusions: The serum anti-H. pylori IgG antibody titer is significantly linked to the bacterial load of the stomach regardless of the antibody producibility of the host. The serum anti-H. pylori IgG antibody test can be used for estimating the burden of bacteria in immunocompetent host with H. pylori infection. Tu1723 Difference of Micoromucosal Patterns of the Gastric Corpus Mucosa BetweenHelicobacter pylori-Associated and Autoimmune Gastritis Patient Noriya Uedo*, Ervin Toth, Ryu Ishihara, Tomofumi Akasaka, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Artur Nemeth, Gabriele W. Johansson, Henrik Thorlacius, Hiroyasu Iishi Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan; Endoscopy, Skane University Hospital, Malmo, Sweden; Surgery, Skane University Hospital, Malmo, Sweden Background: Helicobacter pylori (H. pylori)-associated gastritis and autoimmune gastritis are two major entities of chronic atrophic gastritis. However, characteristic of micromucosal pattern observed by magnifying endoscopy of these diseases has not been fully investigated. Aim of this study is to compare magnifying endoscopic appearance between H. pylori-associated and autoimmune gastritis. Methods: Six H. pylori naive, 14 H. pylori-associated gastritis and 7 autoimmune gastritis patients were enrolled in this study. A videoendoscope, EVIS GIFFQ260Z, that can be used in high-resolution white light, autofluorescence (AFI) and magnifying narrow band imaging (M-NBI) modes was used to evaluate mucosal features. Extent of mucosal atrophy in the corpus was determined as extent of greenish areas in AFI. A 2 2 cm area at the lesser curvature of the corpus about 4 cm proximal to the angulus was set as the region of interest for evaluation of micromucosal patterns. The micromucosal patterns were classified into Foveola and Groove type according to magnifying chromoendoscopic and M-NBI findings. The Foveola type mucosa was characterized as mucosa with round, oval, or short linear foveolae (gastric pits) on magnifying chromoendoscopy. On M-NBI, it had network of dark brown subepithelial capillary that surround light brown epithelium. The Groove type mucosa was characterized by mucosal crests or papillae that were divided by continuous grooves on magnifying chromoendoscopy, and had light brown epithelium that encase dark brown subepithelial capillary. Proportion of the micromucosal patterns were categorized as, Foveola O80%; Foveola 50-80%; Groove 50-80%; and Groove O80%. Biopsy sample was taken from the region of interest to evaluate histological grade of gastritis. Results: All H. pylori naive patients had purple corpus mucosa and the micromucosal pattern was Foveola type. 10 of 14 (71%) patients with H. pylori-associated gastritis showed medium to large greenish atrophic mucosa at the lesser curvature of the corpus, and 13 of 14 (93%) had various proportion of groove type mucosa. All autoimmune gastritis patients had large area of greenish mucosa in the entire corpus but most (O80%) of micromucosal pattern was Foveola type. The biopsy specimen in H. pylori-associated gastritis patients had higher grade of intestinal metaplasia than that in autoimmune gastritis patients. Conclusion: Micromucosal pattern of the gastric corpus mucosa in H. pylori associated-gastritis patients was unlike to that of autoimmune gastritis patients suggesting different pathogenesis of these diseases AB572 GASTROINTESTINAL ENDOSCOPY Volume 81, No. 5S : 2015 Summary of endoscopic appearances