Abstract
We previously reported the presence of a white opaque substance (WOS), opaque to the endoscope light, inside the epithelium when we use magnifying endoscopy (ME) to examine gastric epithelial neoplasia (adenomas and carcinomas) and chronic gastritis (intestinal metaplasia). Through further pathohistological study we elucidated that this substance is comprised of minute lipid droplets (LDs) accumulated below the mucosal epithelium of gastric epithelial neoplasia or intestinal metaplasia. These minute LDs strongly backscatter the projected light, and are visualized as a white substance. When we examined colorectal neoplastic lesions (adenomas and carcinomas) using ME, we observed WOS as in the stomach. However, it is unclear whether WOS in colorectal epithelial tumors is in fact an accumulation of LDs as in the stomach.
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