Tu1163 Macroscopic Features of Neuroendocrine Colorectal Cancers: A 10-Year Retrospective Study

Abstract

vs. jejunum 90% vs. ileum 93%, p< 0.001). There was no significant difference in mean age at diagnosis, sex, or the number of additional primary cancers between the three primary sites. Using KM methods, five-year survival was marginally better for duodenal and ileal lesions than jejunal lesions (duodenum 67% vs. jejunum 66% vs. ileum 61%, p=0.045). However, on CPH analysis, duodenal lesions had significantly better survival than jejunal or ileal lesions (jejunum vs. duodenumHR 1.845 [95% CI 1.461-2.329] p<0.001, ileum vs. duodenal HR 1.665 [95% CI 1.388-1.999], p<0.001), controlling for age, stage, year of diagnosis, sex, race, marital status, and cancer-directed surgery. Conclusion: Epidemiology and survival patterns of SICs vary based on intestinal location. As duodenal lesions are diagnosed at an earlier stage and associated with significantly improved survival than jejunal or ileal lesions, it may be possible to avoid high-risk surgery for selected lesions in these patients.