Abstract
ERCP is a technically challenging procedure rarely associated with serious post-procedure complications. Pregnancy promotes cholelithiasis due to hormonal changes and ERCP may be needed during pregnancy. Limited clinical data are available on the outcomes of ERCP in pregnancy due to the limited number of cases. We performed a systematic review and a meta-analysis to assess the safety of ERCP in pregnancy. A systematic search of PubMed, Medline/Ovid, Web of Science, and Google Scholar through November 20th, 2017 using PRISMA and MOOSE guidelines identified 26 studies that reported the outcomes of ERCP in pregnancy. Random-effects pooled event rate and 95% confidence intervals were estimated. Heterogeneity was measured by I2 and meta-regression analysis was conducted. 26 studies reporting on 1298 pregnant patient who underwent ERCP were identified. Median age was 27.1 years. The pooled event rate for overall non-pregnancy related complications in pregnant patients was 0.122 (95% CI=0.105-0.142; p-value < 0.01). Sub-group analysis showed that the pooled rates of Post ERCP Pancreatitis (PEP) and bleeding were 0.117 (95%CI=0.100-0.137) p-value < 0.01 and 0.046 (95%CI=0.029-0.073) p-value < 0.01 respectively. The pooled event rate for overall pregnancy-related complications was 0.070 (95% CI 0.035-0.134) p-value < 0.01. Substantial heterogeneity was noted in the analysis. ERCP done by experienced endoscopists is a safe procedure during pregnancy with careful selection of cases and limited use of fluoroscopy the maternofetal complications could be reduced.Overall pregnancy-related complications meta-analysis forest plot.View Large Image Figure ViewerDownload Hi-res image Download (PPT)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
