Tu1016 Prevalence of Synchronous Oligopolyposis in Hispanics With Incident Colorectal Cancer: A Population-Based Analysis

Abstract

Background: In Puerto Rico (PR), Colorectal Carcinoma (CRC) is the first cause of cancer death and the second most common cancer among men and women. Familial CRC accounts for 10-15% of all CRCs and several studies suggest that inheritance has a significant impact in the pathogenesis of up to a third of all CRC cases. Little is known about the prevalence of polyposis syndromes among Hispanic individuals and statistics are needed to help quantify disease burden. Aim: To determine the prevalence of oligopolyposis (defined as ≥20 synchronous colorectal adenomas) among Hispanics with incident CRC. Methods: Pathological reports from patients with biopsies positive for CRC from 2007 to 2011 were retrieved from the Puerto Rico Central Cancer Registry. A total of 4334 pathological reports were initially obtained, and after the inclusion/exclusion criteria were implemented, 1685 reports were included in the final analysis. Reports were analyzed by age, gender, stage at diagnosis and colorectal location (proximal vs. distal). Colorectal polyp burden was calculated using pathology reports and normalization of data based on colon segment size. Computer software STATA 10.0 was used for the analysis of data. Results: A total of 1685 colectomy specimens with colorectal carcinoma were analyzed. Of those 46.5% were female; 100% of pathologies were interpreted as colonic adenocarcinoma. The mean patient age was 68 years (SD ± 11) with an age distribution of: 75 (27.8%). The majority of tumors were classified as Stage III (40.3%), while the rest were Stage 0 (2.9%), Stage I (19.5%), Stage II (32.2%), and Stage IV (4.93%). The mean number of polyps was 11 (SD ± 9.6) after normalization of results; with a number of polyps per age group: 50 years (96.5%), had tumors located in the proximal colon (62.3%), and had earlier stage at diagnosis (35.9%) compared to patients without oligopolyposis (p<0.001). Conclusion: In our cohort of Hispanics with incident CRC, oligopolyposis (≥20 synchronous adenomas) was seen in 10%of cases. Our observations suggest that genetic syndromes associated with colorectal polyposis may account for a higher than expected number of CRC cases.