Abstract

The hyperthyroidism in Graves’ disease is caused by circulating autoantibodies which stimulate the thyroid gland (Burman and Baker, 1985). If these antibodies are present in a pregnant woman, they may cross the placenta and cause transient neonatal hyperthyroidism (Munro et al. , 1978). Delays in treatment or failure to detect neonatal hyperthyroidism may lead to chronic complications such as mental impairment or craniosynostosis (Daneman and Howard, 1980). A method to predict and diagnose neonatal hyperthyroidism would be valuable. Historically, methods to detect Graves1 autoantibodies involved laborious and difficult bioassay (Hensen et al. , 1984). We report here the use of a simple, commercially available radioimmunoassay to detect Graves1 autoantibodies in four cases of neonatal hyperthyroidism.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.