Abstract
The dynamics of pituitary TSH secretion have been studied in the female rat throughout prolonged goitrogencsis (3 weeks to one year) and during readjustment of the pituitary-thyroid system after removal of the goitrogenic stimulus (2–21 days). TSH levels in sera of rats 5–15 months old are relatively constant but hormone concentration in the adenohypophysis is more variable and falls substantially in the old animal. With chronic PTU treatment, blood thyrotrophin levels increase 70-300% and pituitary hormonal stores decrease to less than 5% of normal. Goitrogen withdrawal results in heightened accumulation of hormone stores in the pituitary (4–8 fold increase) with peak of rebound at 6–12 days. TSH rebound in the adenohypophysis is associated with return of AF-positive glycoprotein granulation in the thyroidectomy cell. Blood TSH titers during pituitary repletion remain at nearly normal levels. Doses of triiodothyronine and thyroxine which normally induce almost complete disappearance of thyrotrophin from ...
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