Abstract
It has been known for many years that transmissible spongiform encephalopathy (TSE) agents exhibit strain variation [1], a phenomenon that has been studied most extensively in experimental mouse models. Numerous distinct TSE strains have been isolated in mice from a range of scrapie, bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob disease (CJD) sources. The methods used for TSE strain discrimination are based on simple observations of disease characteristics, the most useful being the length of the incubation period of the disease and the type and extent of the pathological changes seen hi the brains of infected animals [24]. Formal strain typing protocols in mice, based on incubation periods and neuropathology, have been used extensively as tools in basic research, for example in studies exploring the nature of TSE agents.
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