Abstract

The production of ergot alkaloids and the metabolism of tryptophan of submerged cultivated ergot mycelia of different ages have been compared. It has been shown that intensity of tryptophan metabolism, concentration of tryptophan in the cell and amounts of different tryptophan metabolites found in the medium are considerably influenced by the age of the mycelium. A connection appears to exist between concentration of tryptophan in the cell, intensity of degradation of tryptophan through a transaminase reaction, and production of alkaloids. Conditions favouring hydroxylation of indole-3-acetic acid to 5-hydroxyindole- 3-acetic acid promote alkaloid production.

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