Abstract
Summary1. Urinary excretion of 5-hydroxyindolylacetic acid and 3-indoleacetic acid was estimated in 10 patients suffering from schizophrenia both before and for 3 days after feeding of tryptophan. Similar studies were made on 10 normal subjects also. 2. Urinary excretion of 3-indoleacetic acid increased both in normal and schizophrenic subjects after administration of tryptophan. Tryptophan also gave rise to increase in urinary excretion of 5-hydroxyindolylacetic acid in schizophrenia but no significant rise was detected in normal subjects. 3. Urinary excretions of nicotinic acid, quinolinic acid, NMN, 6-pyridone, tryptophan, kynurenin, anthranilic acid and 3-hydroxyanthranilic acid were estimated in 10 schizophrenic subjects before and for 3 days after feeding of tryptophan. 4. Nicotinic acid, quinolinic acid, NMN and 6-pyridone were present in urine initially and they were excreted in greater quantities after tryptophan feeding. Tryptophan which was initially absent also appeared in urine after its admi...
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