Abstract
The adaptive response of liver tryptophan pyrrolase ( l-tryptophan: oxygen oxidoreductase, EC 1.13.1.12) of guinea pig to hormone and substrate treatment was investigated and the results compared with similar studies on other species. Tryptophan treatment caused a marked increase in the tryptophan pyrrolase activity, and this increase was only slightly inhibited by actinomycin D. The administration of glucocorticoids increased the incorporation of [ 3H]uridine into ribonucleic acid of guinea pig liver (and decreased that into ribonucleic acid of guinea pig thymocytes), but it failed to induce tryptophan pyrrolase. Two forms of tryptophan pyrrolase (oxidized and reduced forms) were demonstrated in the soluble fraction of liver homogenate from guinea pig.
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